Palladium(0)/PAr3-Catalyzed Intermolecular Amination of C(sp(3))H Bonds: Synthesis of -Amino Acids

摘要

An intermolecular C(sp(3))H amination using a Pd-0/PAr3 catalyst was developed. The reaction begins with oxidative addition of R(2)NOBz to a Pd-0/PAr3 catalyst and subsequent cleavage of a C(sp(3))H bond by the generated PdNR2 intermediate. The catalytic cycle proceeds without the need for external oxidants in a similar manner to the extensively studied palladium(0)-catalyzed CH arylation reactions. The electron-deficient triarylphosphine ligand is crucial for this C(sp(3))H amination reaction to occur.