Asymmetric Dearomatization of beta-Naphthols through an Amination Reaction Catalyzed by a Chiral Phosphoric Acid

摘要

A highly efficient catalytic asymmetric dearomatization of naphthols by means of an electrophilic amination reaction catalyzed by chiral phosphoric acid is presented. This protocol provides a facile access to functionalized -naphthalenone compounds with a chiral quaternary carbon center in excellent yields and enantioselectivity (up to 99% yield, up to 96%ee).