Cationic Ir/Me-BIPAM-Catalyzed Asymmetric Intramolecular Direct Hydroarylation of α-Ketoamides

摘要

Asymmetric intramolecular direct hydroarylation of a-ketoamides gives various types of optically active 3-substi-tuted 3-hydroxy-2-oxindoles in high yields with complete regioselectivity and high enantioselectivities (84-98% ee). This is realized by the use of the cationic iridium complex [Ir(cod)2](BAr~F4) and the chiral O-linked bidentate phosphor-amidite (R,R)-Me-BIPAM.