α-MsO/TsO/Cl Ketones as Oxidized Alkyne Equivalents: Redox-Neutral Rhodium(III)-Catalyzed C—H Activation for the Synthesis of N-Heterocycles

摘要

α-Halo and pseudohalo ketones are used for the first time as C(sp~3)-based electrophiles in transition-metal-catalyzed C—H activation and as oxidized alkyne equivalents in Rh~(III)-catalyzed redox-neutral annulations to generate diverse N-heterocycles. This transformation is efficient and scalable. Due to the mild reaction conditions, a variety of functional groups could be tolerated.