Nickel-Catalyzed C—H Alkylations: Direct Secondary Alkylations and Trifluoroethylations of Arenes

摘要

A versatile nickel catalyst allowed for C—H alkylations of unactivated arenes with challenging secondary alkyl bromides and chlorides. The high catalytic efficacy also set the stage for direct secondary alkylations of indoles as well as C—H trifluoroethylations with ample substrate scope.