Ligand-Controlled α- and β-Arylation of Acyclic N-Boc Amines

摘要

The palladium-catalyzed ligand-controlled arylation of α-zincated acyclic amines, obtained by directed α-lithiation and transmetalation, is described. Whereas PtBu3 gave rise to α-arylated Boc-protected amines, more flexible N-phenyl-azole-based phosphine ligands induced major β-arylation through migrative cross-coupling.