Site-Differentiated Polyboron Arenes Prepared by Direct C—H Borylation and Their Highly Selective Suzuki-Miyaura Cross-Coupling Reactions

摘要

Di-and polyboron (hetero)arenes, site-differentiated with MIDA boronyl (MIDA = N-methyliminodiacetic acid) and pinacolato boronyl (Bpin), were prepared by an iridium-catalyzed direct C~H borylation of readily available (hetero)-aryl MIDA boronates. The excellent synthetic uses of these multisite nucleophiles were demonstrated by the high-yield production of a variety of multifunctionalized poly-(hetero)arenes with the highly chemoselective Suzuki-Miyaura coupling (SMC) of the Bpin moiety being an essential step.