Scalable Rhodium-Catalyzed Intermolecular Aziridination Reaction

摘要

Aziridines are strained three-membered rings composed of one nitrogen atom and two carbon atoms. Over the last several decades aziridines have been shown to be incredibly useful and versatile synthetic intermediates. The diversity of reactions which employ aziridines is such that with the proper selection of precursors having an appropriate nitrogen substituted (X), this strained motif can be employed in a variety of downstream processes (Figure 1). Although aziridines are not common as naturally occurring motifs, mitomycin C is an example of an important natural product containing an aziridine and is an approved chemotherapeutic agent (Muta-mycin) for treating several types of cancer.