Near-Infrared- and pH-Responsive System for Reversible Cell Adhesion using Graphene/Gold Nanorods Functionalized with i-Motif DNA

摘要

Cell adhesion plays a central role in multicellular organisms and disease because it is not only a physical link to the environment, but also can activate signaling pathways that have profound effects on cell fate and diverse physiological processes, including wound healing, tissue repair, and cancer metastasis. Molecular approaches to control cell adhesion and migration hold considerable promise in tissue engineering, medical implantation and immunological response. Recently, dynamic substrates that can mimic the characteristics of the natural extracellular matrix (ECM) and turn surface properties "on" or "off" with external stimulus have attracted much attention. Thus far, the switchable surfaces have been engineered to respond to an electric field, UV/ Vis light, temperature, chemical stimuli, enzymatic activities, and magnetic field.