An 'Against the Rules' Double Bank Shot with Diisobutylaluminum Hydride To Allow Triple Functionalization of α-Cyclodextrin

摘要

A dual characteristic of highly symmetrical concave molecules is that on the one hand they possess a cavity that confers them with a multitude of applications whilst on the other they are inherently difficult to regioselectively functionalize. Cyclodextrins (CDs) are typical in this respect. Native CDs are widely used in commercial formulations of drug molecules to increase their solubility, bioavailability, and stability, and have also been widely used in combination with polymers to modulate their properties. In the realm of catalysis, both native and uniformly modified CDs have very successfully served as mass-transfer additives.