Pseudorotaxanes with Self-Sorted Sequence and Stereochemical Orientation

摘要

Self-sorting is a fundamental process in living systems which controls the spatiotemporal organization of complex mixtures of biomolecules,' such as proteins, nucleic acids, oligosaccharides, and lipids, into large functional assemblies (e.g. the DNA double helix, multienzyme complexes,' riboso-mes, or membranes) and beyond these assemblies into cellular compartments essential for the development of life. Stereochemical homogeneity as well as precise building-block sequences-that is, accurate control of sequence isomerism-are pivotal for biomolecular function. For example, the sequence of only four DNA bases defines the genetic code. Control of the stereochemical and sequence information by self-sorting is thus of prime importance for life.