Multiple Parallel 2D NMR Acquisitions in a Single Scan

摘要

Parallel receiving technologies have recently crossed the boundary separating magnetic resonance imaging from nuclear magnetic resonance (NMR) spectroscopy. In the latter case they promise significant time-saving advantages, by enabling the detection of multiple spectra simultaneously rather than in series. Moreover the full compatibility of parallel receiving with all other advances of contemporary NMR spectroscopy promises to open even further synergies in terms of speed and analytical capabilities. The present study shows one such instance, whereby the combination of parallel receiving multinuclear technologies is made with gradient-based spatial encoding methods, to yield multiple multidimensional NMR spectra in a single scan. The potential of this combination is demonstrated by the parallel acquisition of 2D ~1H-~1H and ~1H-S correlation spectra involving different S nuclei (~(19)F, ~(31)P), within a single transient. Besides its potential conceptual message about what is nowadays within reach of NMR spectroscopy, the ensuing two-dimensional parallel ultrafast NMR spectroscopy (2D PUFSY) experiment carries new opportunities for high-throughput analyses, chemical kinetics, and fast experiments on meta-stable hyperpolarized solutions.