Site-Selective Catalytic C(sp~2)H Bond Azidations

摘要

Organic azides are key structural motifs in compounds of relevance to biology, medicinal chemistry, and materials science. Thus, various azido-substituted compounds, such as azidothymidine (1, AZT), azidocillin (2), or the COX-2 inhibitor and colecoxib derivative 3, exhibit valuable biological activities (Scheme 1). Moreover, the unique reactivity of organic azides resulted in numerous applications as versatile intermediates in organic synthesis, most notably in the copper-catalyzed 1,3-dipolar Huisgen cycloaddition.