Enantioselective Copper-Catalyzed [3+3] Cycloaddition of Azomethine Ylides with Azomethine Imines

摘要

The 1,3-dipolar cycloaddition has been established as a reliable and powerful tool for the synthesis of heterocyclic compounds from simple starting materials. In particular, the catalytic asymmetric 1,3-dipolar [3+2] cycloaddition of azomethine ylides with electron-deficient alkenes for the enantioselective preparation of structurally diverse pyrrolidines is probably one of the most studied asymmetric 1,3-dipolar cycloaddition reactions (Scheme la), and considerable progress has been made since the pioneering contributions from the research groups of J0rgensen and Zhang.