Biomimetic Dehydrogenative Diels-Alder Cycloadditions: Total Syntheses of Brosimones A and B

摘要

Nature creates an intriguing array of molecular architectures that has attracted extensive investigations on natural product identification, origin, biological activities, and chemical synthesis. In particular, biosynthetic studies have inspired elegant biomimetic total synthesis of natural products. Herein, we report biomimetic syntheses of the natural products brosimones A and B featuring multicatalytic dehydrogenative Diels-Alder (DHDA) cycloadditions of 2'-hydroxychalcones.