Aptamer-Guided Caging for Selective Masking of Protein Domains

摘要

The exogenous control of biological phenomena is of critical importance to study macromolecular function in spatiotem-poral resolution. The recent years have seen many approaches being developed and among them photochemical tools using photoswitches or phototriggers (so-called "cages") have gained emerging interest. The caging strategy uses photo-labile groups in strategic locations to temporarily block a function and liberate it upon need with light under exact control of location and time.