Pot Economy in the Synthesis of Prostaglandin A1 and E1 Methyl Esters

摘要

The efficient total synthesis of natural products has always been a critical issue for organic chemists, especially when the molecule to be prepared possesses important biological activity and is difficult to obtain from natural sources. A lot of effort has been devoted to the development of the ideal synthesis. Recently, when synthesizing molecules we not only have to consider efficiency but also sustainability, as indicated by terminology such as atom economy, step economy and redox economy. Protecting-group-free and toxic-metal-free syntheses would also contribute to sustainability, and catalytic reagents (as selective as possible) are regarded as superior to stoichiometric reagents according to the 12 principles of green chemistry.