Construction of Eight-Membered Carbocycles through Gold Catalysis with Acetylene-Tethered Silyl Enol Ethers

摘要

The development of efficient methods for the construction of medium-sized (eight- to eleven-membered) carbocycles remains an important challenge in organic synthesis. Despite their ubiquitous existence within various biologically active natural products and pharmaceuticals (Figure 1), the formation of medium-sized rings is generally difficult because of entropic effects and transannular interactions.