Decarboxylative Cross-Coupling of Mesylates Catalyzed by Copper/ Palladium Systems with Customized Imidazolyl Phosphine Ligands

摘要

Decarboxylative cross-coupling reactions have recently emerged as a powerful methodology for the regioselective construction of C—C and C—heteroatom bonds. Their key advantage over traditional cross-coupling reactions is that they draw on stable and readily available carboxylate salts as sources of carbon nucleophiles rather than expensive and sensitive organometallic reagents. In the last decade, a rapidly growing number of decarboxylative reactions have been discovered including decarboxylative Heck reactions, ally-lations, redox-neutral cross-coupling reactions, oxidative coupling reactions, C—H arylations, homocouplings, and Chan-Lam-type reactions.