Copper-Catalyzed Oxidative Cross-Coupling of Sulfoximines and Alkynes

摘要

Until recently, the cross-coupling of two electron-rich nucleo-philic substrates presented a significant challenge for synthetic organic chemists. In the past decade, however, several breakthroughs have been reported for such processes, such as employing transition-metal catalysts to facilitate the formation of either a new C-C or C-N bond between two nucleophiles. Realizing that this approach could also open access to N-alkynylated sulfoximines (2), which represent an essentially unexplored substrate class, we considered oxidative cross-coupling methods for the construction of the respective C-N bonds (Scheme 1).