Desymmetrization of meso-2,5-Diallylpyrrolidinyl Ureas through Asymmetric Palladium-Catalyzed Carboamination: Stereocontrolled Synthesis of Bicyclic Ureas

摘要

Catalytic asymmetric desymmetrization reactions are powerful and efficient tools for the synthesis of chiral molecules. These transformations convert simple achiral substrates into complex enantioenriched products through the differentiation of two enantiotopic groups, and can generate complex structures that bear multiple stereocenters in a highly controlled fashion. As such, the development of asymmetric desymmetrization reactions that allow for the construction of important structural motifs is of considerable utility.