Mycalol: A Natural Lipid with Promising Cytotoxic Properties against Human Anaplastic Thyroid Carcinoma Cells

摘要

The high-mobility group A (HMGA, types 1 and 2) proteins are low-molecular-weight nuclear factors that orchestrate the assembly of nucleoprotein complexes involved in gene transcription, replication, and chromatin structure. HMGAs possess oncogenic activity and proteins of type 1 (HMGA1) have been correlated to cellular invasiveness and drug-resistance in human malignancies. In particular, blockage of expression of these proteins significantly enhances the responsiveness of tumor cell lines that are otherwise resistant to cytotoxic agents. Thus, phenotypic assays based on cells with reduced levels of HMGA are a possible tool for a rational search of novel compounds against tumors whose aggressiveness and resistance reduce the success of normal screening methods.