Enantioselective Alkynylbenzaldehyde Cyclizations Catalyzed by Chiral GoId(I) Acyclic Diaminocarbene Complexes Containing Weak Au-Arene Interactions

摘要

Catalysis with gold(I) has emerged as a powerful tool for the synthesis of complex organic structures, owing to the ability of Au~I to activate a variety of unsaturated bonds toward nucleophilic attack. In efforts to develop enantioselective catalysts, the linear coordination geometry of Au~I presents challenges because of the remoteness of chiral ligand substituents and the inability of substrates to adopt a chelate binding mode that favors asymmetric induction. Nevertheless, high enantioselectivities have been achieved with gold catalysts in an impressive number of reactions.