Non-Enzymatic Dynamic Kinetic Resolution of Secondary Aryl Alcohols: Planar Chiral Ferrocene and Ruthenium Catalysts in Cooperation

摘要

Methods for the synthesis of optically active compounds are important for the preparation of pharmaceuticals, agricultural chemicals, and materials for electronics and optics, and thus, the synthesis of chiral derivatives is an important area of contemporary synthetic organic chemistry. One of the most appealing methodologies to achieve this goal is dynamic kinetic resolution (DKR). This strategy consists of the combination of a selective kinetic resolution and a fast enough racemization process in a one-pot transformation. This approach allows for the conversion of both enantiomers of a racemic substrate into a single enantiomer of the product. Thereby, the limitation of kinetic resolution, which provides a maximum yield of 50% for a particular enantiomer, is overcome (Scheme 1).