Oxidative Trifluoromethylation of Unactivated Olefins: An Efficient and Practical Synthesis of α-Trifluoromethyl-Substituted Ketones

摘要

The incorporation of a CF3 group in a compound of pharmacological relevance usually results in significant enhancement of its lipophilicity, binding selectivity, and metabolic stability. A number of highly effective methods for the incorporation of a CF3 moiety into commonly used synthetic scaffolds have been reported. In this context, the synthesis of α-CF3-substituted carbonyl compounds has recently drawn significant attention, owing to their importance for both pharmaceutical and synthetic research.