Copper-Catalyzed Animation of Ketene Silyl Acetals with Hydroxylamines: Electrophilic Animation Approach to 兛-Amino Acids

摘要

兛-Amino acid derivatives are a fundamental and important structural motif in many biologically active compounds and pharmaceutical targets, especially peptide drugs. In particular, significant attention has recently been focused on unnatural a-amino acids because when used to replace natural a-amino acids in the original drug structure, the potential for the discovery of new functions as well as improved activity increases. Multicomponent couplings such as the Strecker, Ugi, and Petasis reactions rank as one of the most powerful approaches to the target structure. As a useful alternative, the decoration of N-protected glycine esters with organic halides under phase-transfer or palladium catalysis conditions has also been widely developed.