A Common Diaryl Ether Intermediate for the Gram-Scale Synthesis of Oxazine and Xanthene Fluorophores

摘要

Recent advances in fluorescence spectroscopy have driven the demand for dyes with improved photophysical and fluorescence properties. In addition to their development as cellular and single-molecule imaging tools, engineered fluorescent dyes have also been developed as environmental sensors that can provide information on local viscosity, pH value, solute concentration, and electrical potential. Current and future developments in this field, especially those relevant to single-molecule and cellular imaging, depend on the synthesis of customized fluorescent dyes that emit in the red region of the visible spectrum, have high extinction coefficients and quantum yields, and display high photostability.