Metal-Free Aryltrifluoromethylation of Activated Alkenes

摘要

The introduction of trifluoromethyl groups into organic molecules has found widespread use in medicinal chemistry because of the improved properties (including permeability and metabolic stability) that fluorine-containing compounds display compared to their C-H counterparts. Transition-metal-catalyzed trifluoromethylation reactions have been developed, as they feature mild reaction conditions and high functional-group compatibility. In this context, reactions that involve the selective difunctionalization of alkenes have received increasing attention, as they enable the formation of C-C/C-heteroatom and C-CF, bonds in a single synthetic operation. Thus, efficient methods for oxotrifluoromethylation and aryltrifluoromethylation reactions that are catalyzed by Pd or Cu complexes have been devised. In contrast, metal-free processes have been much less explored.