A Bioreducible Polymer for Efficient Delivery of Fas-Silencing siRNA into Stem Cell Spheroids and Enhanced Therapeutic Angiogenesis

摘要

Adult mesenchymal stem cells (MSCs) hold great potential for the treatment of ischemic disease because they can contribute to angiogenesis by secreting a broad spectrum of angiogenic growth factors However, the low survival rate and poor engraftment of the transplanted MSCs limit the use of MSC-based therapy in a clinical setting. Recently, it was shown that transplanting stem cells as spheroids of approximately 200 兪m in diameter could be a promising strategy for improving their angiogenic efficacy.