Asymmetric Syntheses of 8-Oxabicyclo [3,2,1] octanes: A Cationic Cascade Cyclization

摘要

8-Oxabicyclo[3.2.1]octane, or 8-oxatropane, is a common structural motif featured in many classes of polycyclic natural products (Figure 1), some of which show interesting biological activities. 8-Oxatropanes are also structural mimics of tropane alkaloids, and consequently there is an increasing interest in their potential pharmaceutical use, particularly against cocaine abuse.