Site-Specific Incorporation of ε-N-CrotonyIlysiee into Histones

摘要

Histones, the major protein components of chromatin, are extensively altered by post-translational modifications (PTMs). Deciphering distinctive patterns of these PTMs (namely the "histone code") is key to understanding the epigenetic regulation of diverse biological processes. For example, lysine acetylation is one of the most common PTMs found in histones, and its regulation has been demonstrated to be closely related to DNA replication/repair, transcriptional regulation of genes, and the status of chromatin assembly. Misregulation of chromatin PTM is linked to various human diseases such as cancer, central nervous system (CNS) disorders,1 and autoimmune diseases. Therefore, the enzymes responsible for lysine acetyl modifications, including histone acetyltransferases (HATs) and histone deacetylases (HDACs), are regarded as important drug targets.