An Asymmetric Hydroformylation Catalyst that Delivers Branched Aldehydes from Alkyl Alkenes

摘要

Enantioselective hydroformylation of alkenes can simultaneously create a new C-C bond, install a very versatile functional group, and produces enantiomerically enriched compounds from very economic reagents: an alkene, carbon monoxide, and hydrogen. Given the precedent for large-scale production of achiral linear aldehydes, hydroformylation can be viewed as potentially the ideal reaction for commercial production of chiral building blocks. However, there have been far more hurdles to overcome relative to core asymmetric production methods such as asymmetric hydrogena-tion, despite decades of research effort.