Ag~I Ion Mediated Formation of a C-A Mispair by DNA Polymerases

摘要

DNA forms a double-stranded structure through the formation of adenine-thymine (A-T) and guanine-cytosine (G-C) Watson-Crick base pairs. The selectivity of the hydrogen bonding between bases is essential for the replication and expression of genetic information. For two decades, the development of an artificial base pair has been an area of research with the goal of expanding the genetic alphabet. Several groups have reported artificial base pairs formed by non-Watson-Crick hydrogen bonding and hydrophobic interaction based on shape complementarity.