Enantioselective Functionalization of Radical Intermediates in Redox Catalysis: Copper-Catalyzed Asymmetric Oxytrifluoromethylation of Alkenes

摘要

Transition-metal-catalyzed alkene difunctionalization represents a versatile and step-economical strategy for the enhancement of molecular complexity, as it accesses multiple carbon-carbon/carbon-heteroatom bonds and stereogenic centers in a single step from simple precursors. One of the most synthetically important transformations of this class is the radical addition of alkenes catalyzed by a transition-metal redox system In a typical catalytic cycle (Scheme 1 a), a metal-generated radical adds across the alkene to give the nascent carbon radical intermediate A.