Direct Functionalization of Tetrahydrofuran and 1,4-Dioxane: Nickel-Catalyzed Oxidative C(sp~3)-H Arylation

摘要

Tetrahydrofuran (THF) and 1,4-dioxane are important basic chemical feedstocks. Moreover, such five- or six-membered ring moieties frequently occur within the framework of many important organic compounds (selected examples are shown in Figure 1). However, to construct tetrahydrofuran or 1,4- dioxane rings in complex organic molecules is sometimes challenging and usually requires cumbersome synthetic routes. Therefore, direct functionalization of THF or 1,4-dioxane to introduce these simple molecules into complex organic compounds is important for the synthetic chemistry community. Owing to their lack of reactivity under many reaction conditions, direct functionalization is a challenging task, which is why these species are among the most widely used solvents in both academia and industry.