Gold-Catalyzed Intramolecular Regio- and Enantioselective Cycloisomerization of 1,1-Bis(indolyl)-5-alkynes

摘要

Indole is one of the most intensively investigated aromatic heterocycle, because its derivatives are abundant in nature and possess various biological activities. Among the large number of indoles, bis(indole) alkaloids, such as hamacan-thins, nortopsentins, and dragmacidins (Scheme 1), are par- ticularly abundant in marine sponges. In bis(indole) alkaloids, two indole moieties are connected to various heterocyclic units. Compounds with 'this structural motif exhibit a wide spectrum of pharmacological activities, including antibacterial, antiviral, and cytotoxic activities, which make bis(indole) alkaloids and their analogues attractive targets for biomedical and synthetic studies.