Manganese Oxide Promoted Liquid-Phase Aerobic Oxidative Amidation of Methylarenes to Monoamides Using Ammonia Surrogates

摘要

Selective functionalization of sp~3-hybridized C-H bonds of hydrocarbons, for example alkylarenes, to value-added products is of crucial importance. With regard to oxidation of alkylarenes, there have been many efforts to find efficient catalysts to date. For example, toluene, the simplest and readily available alkylarene, has been catalytically converted into oxidized products, such as benzyl alcohol, benzaldehyde, and benzoic acid. Currently, benzonitrile and cyanopyr-idines have been produced by catalytic ammoxidation of toluene and methylpyridines, respectively. These products, namely alcohols, aldehydes, carboxylic acids, and nitriles, are commercially very important as versatile intermediates in the manufacture of pharmaceuticals, agricultural chemicals, perfumes, dyes, solvents, and specialty chemicals.