Deciphering Aromatic Oligoamide Foldamer-DNA Interactions

摘要

Foldamers are artificial folded molecular architectures inspired by the structures of biopolymers. Some synthetic foldamers feature properties that make them promising candidates for the selective recognition of protein and nucleic acid surfaces: they adopt well-defined and predictable conformations that can be decorated with proteinogenic side chains; they are medium sized (0.5-5 kDa); they are often resistant to proteolytic degradation, and some show good cell penetration ability.