A Structural Basis for the Antibiotic Resistance Conferred by an A1408G Mutation in 16S rRNA and for the Antiprotozoal Activity of Aminoglycosides

摘要

Aminoglycosides are broad spectrum oligosaccharide antibiotics acting against a variety of Gram-negative and certain Gram-positive bacteria. Their antibacterial mechanism has been revealed at the atomic level by several crystallographic studies of the 30S ribosomal particles, the 70S full ribo-somes, and model oligonucleotides in complex with various 2-deoxystreptamine aminoglycosides.