A Catalytic Multicomponent Approach for the Stereoselective Synthesis of cis-4,5-Disubstituted Pyrrolidinones and Tetrahydro-3H-pyrrolo [3,2-c] quinolines

摘要

Pyrrolidinones are privileged structures in pharmaceutical development. In particular, cis-4,5-disubstituted pyrrolidinones containing aromatic and heteroaromatic groups were identified as lead structures for inhibition of type II 17β-hydroxysteroid dehydrogenase, which is implicated in the treatment of osteoporosis. Likewise, cis-4,5-diarylated pyrrolidinones have been reported to inhibit transcription factor HOXA13, a regulator of mammalian development'21 and of certain cancer types.