Dioxindote in Asymmetric Catalytic Synthesis: Routes to Enantioenriched 3-Substituted 3-Hydroxyoxindoles and the Preparation of Maremycin A

摘要

Many biologically active compounds and natural products possess an oxindole framework with a hydroxy-bearing tetrasubstituted stereogenic center at C3 (Scheme 1). It has been shown that a defined three-dimensional spatial arrangement of this structural element greatly influences the biological activity. This observation has provided the impetus to develop highly stereoselective routes to this particular target structure.