Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of Allylic Alcohols by an Enantioselective Isomerization/Transfer Hydrogenation Mechanism

摘要

Asymmetric transfer hydrogenation (ATH) has emerged as a major pathway in asymmetric catalysis since it can be performed with a large variety of substrates, experimental simplicity, and a high level of enantiocontrol. In addition, it uses economical and environmentally friendly hydrogen sources (isopropyl alcohol, formate), and the operational safety is better than of traditional asymmetric hydrogenation using hydrogen gas. ATH has been applied to enantioselective reduction of ketones/aldehydes, imines, activated olefins, and aromatic heterocycles.