Azo-Propofols: Photochromic Potentiators of GABA_A Receptors

摘要

GABA_A receptors are pentameric ligand-gated ion channels that are activated by the major inhibitory neurotransmitter in the mammalian brain, γ-aminobutyric acid (GABA). Binding of GABA results in the opening of a chloride ion selective pore, thus hyperpoiarizing the postsynaptic neuron and decreasing the likelihood of action-potential firing. As such, GABA_A receptors are a prominent target for anesthetic, hypnotic, and anticonvulsant drugs (Scheme 1).