Catalytic C—H Animation with Aromatic Amines

摘要

The prevalence of basic nitrogen atoms in myriads of small molecules of biological interest motivates the development of methodologies to streamline the introduction of nitrogen atoms into organic molecules. C—H amination offers a potentially highly atom-economical approach, directly converting C—H into C—N bonds. Prototypical nitrene-based routes for C_(SP3)-H amination typically employ the iminoiodinanes PhI=N(EWG) (EWG = SO2R' or C(O)OR') as nitrene transfer reagents with a range of catalysts to aminate C—H bonds in the substrates R-H to provide the corresponding secondary amines RNH(EWG).