Transamidation of Primary Amides with Amines Using Hydroxylamine Hydrochloride as an Inorganic Catalyst

摘要

Amide bonds are among the most important linkages in industrial and medicinal chemistry today. While the most common way to make an amide bond is still by using a stoichiometric amount of a coupling reagent, with growing focus on green chemistry, this method is becoming increasingly impractical. Recently, in our group and others, there has been high interest in developing catalytic methods of amide bond formation which avoid using these coupling reagents.