Total Synthesis of (-)-atrop-Abyssomicin C

摘要

In 2004, Siissmuth and co-workers reported the isolation of abyssomicin C, a naturally occurring antibiotic of exotic origin and complex structure. The mechanism of antibiotic activity of abyssomicin C against Gram-positive bacteria, including methycillin- and vancomycin-resistant Staphylococcus aureus strains, was unprecedented: it inhibits tetrahydro-folate biosynthesis at an early stage. In addition to abyssomicin C, several other congeners have been found in both marine and terrestrial Streptomyc.es strains (Scheme l). The combination of strong antibacterial activity and complex molecular architecture made abyssomicin C an attractive synthetic target.