Total Synthesis of (-)-Lycoposerramine-S

摘要

Lycopodium alkaloids have attracted the attention of synthetic chemists because of their intriguing structural features and the remarkable bioactivities. Among them is (-)-lycoposerramine-S (1; Figure 1), which was isolated from Lycopodium serratum by Takayama and co-workers in 2002 and has a unique structure including a highly fused tetracyclic skeleton with two nitrogen atoms and one quaternary carbon center. Although synthetic studies of (-)-lycoposerramine-S were reported by Elliott and co-work-ers, its total synthesis has not been reported to date.