Modular Assembly of a Pd Catalyst within a DNA Scaffold for the Amplified Colorimetric and Fluorimetric Detection of Nucleic Acids

摘要

Catalytic signal amplification is a powerful tool for the detection of chemical and biological analytes. In chemistry it has been employed in sensing various toxic metal ions (e.g. Pd~(2+), Pb~(2+), Cu~(2+), and Hg~(2+)) as well as small molecules such as carbon monoxide and thiols. In a biological context, catalytic reactions have enabled the highly sensitive detection of scarce analytes. They have been widely utilized, for instance, in the detection and assay of proteins, antibodies, and nucleic acids.