Ruthenium-Catalyzed Redox Isomerization of Trifluoromethylated Allylic Alcohols: Mechanistic Evidence for an Enantiospecific Pathway

摘要

The challenge to generate enantiopure molecules featuring a trifluoromethyl motif at a stereogenic carbon center increasingly stimulates high interest in many laboratories. The recent success of the direct introduction of a CF3 group by nucleophilic, electrophilic, or radical processes nicely complements the equally challenging approach of exploiting prochiral trifluoromethylated substrates. The stereoselective construction of an all-C CF3-bearing stereogenic tertiary carbon center without any heteroatom substituent undoubtedly belongs to the most fundamental topics in fluorine chemistry and remains highly challenging.