Cooperation of Two Bifunctional Enzymes in the Biosynthesis and Attachment of Deoxysugars of the Antitumor Antibiotic Mithramycin

摘要

Glycosylation reactions catalyzed by glycosyltransferases (GTs) are important structural modifications that are often necessary for the biological activities of natural products. Studying these is an increasingly important and rigorously pursued research field. Although GTs usually display strict substrate and regiospecificities, some examples were found showing surprising tolerance, which can be exploited in combinatorial biosynthetic approaches.